Basic Information
VIS ID
TVIS10011341
Fusion event
HBV-LOC102724832 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
74216884/73351167 (Hg38)
End
74216884/73351167 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC102724832
Nearest miRNA
hsa-mir-12113/Upstream/7074239; hsa-mir-1243/Downstream/3222401;
Nearest TSS
ENST00000502981/Upstream/91958; ENST00000510166/Downstream/45947;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/91754, chr4-CpG: 20/Downstream/269160
Nearby gene
ANKRD17(-92382) ; ALB(+53088) ;
Upstream sequence
AAAGTCCCAATTTTAAATAATTGTATATTTAACTTTACTTGGACATCTTTTTAACACTATATGTTGGAGTAAAACTACTGTTACAAATTGATCTTCTGTT
Downstream sequence
aatgggatgagtaaaaataatgcgtgcctcttctgggttatttctttaaaaggaaaggCCCTggctgggcgcggtggctcacacctgtaatctcagcact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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