Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011349
Fusion event
HBV-CTNND2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2417
Orient
+
Integrated sequence
TCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCG| |TCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTT
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
Start
End
11282982/11282870 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-10397/Upstream/804725; hsa-mir-103a-1/Downstream/3543059;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/521057, chr5-CpG: 115/Downstream/101699
Nearest cancer related gene
CTNND2(OG, No orient, 0)
Upstream sequence
AAAACTGGAATGAAGACTCATTCTTTTGAAACTCAGCCTCAGATAAATAACAAACTAGGAAATGGAAATCTGTTTCAAGAATTGCAGTAACATCTACTCT
Downstream sequence
GCATACTGATATATCTTTGCCAGATAATGTTTACTCAAAACTCAGGAAACTCATGTTAAAACTTGCCTCGTTCTAGCACTCCCTCTTCCTCAGATCTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.