VISDB Viral Integration Site DataBase

VIS ID

TVIS10011357

Fusion event

HBV-PIK3R1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1803

Orient

-

Integrated sequence

CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA

Chromosome

chr5

Cytoband

q13.1

Reference genome

Start

End

67563527/68267699 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-29a-3p ; hsa-mir-376a-3p ; hsa-mir-29b-3p ; hsa-mir-21-5p ; hsa-let-7a-5p ; hsa-mir-155-5p ; hsa-mir-503-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-646 ; hsa-mir-6838-5p ; hsa-mir-448 ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-190a-3p ; hsa-mir-4524a-5p ; hsa-mir-5011-5p ; hsa-mir-4524b-5p ; hsa-mir-221-3p ; hsa-mir-1277-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-4793-5p ; hsa-mir-3924 ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-455-5p ; hsa-mir-5580-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6721-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-542-3p ; hsa-mir-218-1-3p ; hsa-mir-143-3p ; hsa-mir-128-3p ; hsa-mir-487a-3p ; hsa-mir-486-5p ; hsa-mir-1202 ; hsa-mir-126-3p ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-302a-5p ; hsa-mir-3658 ; hsa-mir-3972 ; hsa-mir-4317 ; hsa-mir-4755-3p ; hsa-mir-5006-5p ; hsa-mir-5007-5p ; hsa-mir-7856-5p ; hsa-mir-924

Nearest miRNA

hsa-mir-10397/Upstream/8563996; hsa-mir-103a-1/Downstream/3901768;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/51141, chr5-CpG: 26/Downstream/20686

Nearest cancer related gene

PIK3R1(OG, No orient, 0)

Upstream sequence

aaatggtctgggggtaaaaaaaggcttcctgggaccagaacataaaaacatacaagataatagaattataaaatgtaagatgtttaacaagctttatata

Downstream sequence

AGTCATTCCAACTTCATTTTGTCTTCACATTCAGAAAACTGAAGTCTAATATCTCAAATATATTAGTATTGTGGTCCTTTTGGGGAAAGTATGATAAATT