Basic Information
VIS ID
TVIS10011360
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2045
Orient
+
Integrated sequence
TACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTG| |TTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCT
Host Sequence
Chromosome
chr6
Cytoband
p23
Reference genome
GRCh37/hg19
Start
13621560/13621328 (Hg38)
End
13621560/13621328 (Hg38)
Orient
+
Location type
downstream
Fragile sites / regions
FRA6A
Target gene
NOL7 ; RANBP9
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-484 ; hsa-mir-196a-5p ; hsa-mir-591
Nearest miRNA
hsa-mir-3691/Upstream/3181534; hsa-mir-10398/Downstream/2520228;
Nearest TSS
ENST00000381078/Upstream/5739; ENST00000607518/Downstream/11427;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/5657, chr6-CpG: 217/Downstream/89419
Nearest cancer related gene
RANBP9(TSG, No orient, 0)
Upstream sequence
AGGTTAACTATTTCTATCCCACTGTATCTTTTCCCAAGAGAGACCAGGTTTCTTGACTGGAATAAAGTACTTCAAAACTCTGTAACAATTTTATTACTCA
Downstream sequence
CCACAATATCAGGTCTAACCCTAATCCAGGGATGCCAGTAAACTGAAGGCAATTTTAGGTTGTAGAACTCAGATTAATTGTAGAAACCATTAATTTTAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate