Basic Information
VIS ID
TVIS10011361
Fusion event
HBV-LOC105374943 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1808
Orient
-
Integrated sequence
TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCAC| |CAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGAC
Host Sequence
Chromosome
chr6
Cytoband
p23
Reference genome
GRCh37/hg19
Start
14397123/14396892 (Hg38)
End
14397123/14396892 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6A
Target gene
LOC105374943
Nearest miRNA
hsa-mir-3691/Upstream/3957098; hsa-mir-10398/Downstream/1744664;
Nearest TSS
ENST00000381078/Upstream/2566; ENST00000474854/Downstream/202798;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/185379, chr6-CpG: 113/Downstream/847754
Nearby gene
CD83(-259975) ; JARID2(+849083) ;
Upstream sequence
AGGAAAACAACATTTGTGTGTGGCAGAGTCCTACTTATTACGGGCTACACATTTAAAGCCTTTGCAGTCTTCCCTACAAACGAAAGTAAGAGAAGTTTCG
Downstream sequence
TGGATAGGATATACATGCAAGCGTGTGAGTTTATTTGTGTTTATATGAGTATATAGAAGAAATCCAAATCTCCCCAAGCTCCTTCAATCTGTGACTAGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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