Basic Information
VIS ID
TVIS10011364
Fusion event
HBV-LOC101928923 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1899
Orient
+
Integrated sequence
TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG| |GGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATA
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
156294707/155973573 (Hg38)
End
156294707/155973573 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101928923
Nearest miRNA
hsa-mir-10398/Upstream/26694; hsa-mir-1913/Downstream/806105;
Nearest TSS
ENST00000381078/Upstream/517670; ENST00000637910/Downstream/525393;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/658825, chr6-CpG: 41/Downstream/423364
Nearby gene
NOX3(-517670) ; ARID1B(+804357) ;
Upstream sequence
aacaaaaaacaaaaaatggtgagaggcaaaaaatcatatgcttccatatacgtacttaaagttcaaagagtagaaaaaatatatagtattcagccctata
Downstream sequence
TGGAAAAGTAAAAGAATGAGGCTGCTTCTCACGTATTGGAAGGGAGGGGGAGGAAGCACCTAAGATGTTTGCTGTGATCCATGTTCTAAATGAACACTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate