VISDB Viral Integration Site DataBase

VIS ID

TVIS10011367

Fusion event

HBV-RREB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1927

Orient

-

Integrated sequence

CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT| |TTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTT

Chromosome

chr6

Cytoband

p24.3

Reference genome

Start

End

7203123/7202890 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-671-5p ; hsa-mir-106b-5p ; hsa-mir-30d-5p ; hsa-mir-145-5p ; hsa-mir-143-3p ; hsa-mir-889-3p ; hsa-mir-3653-3p ; hsa-mir-3658 ; hsa-mir-224-3p ; hsa-mir-137 ; hsa-mir-522-3p ; hsa-mir-4694-3p ; hsa-mir-4729 ; hsa-mir-485-3p ; hsa-mir-539-3p ; hsa-mir-582-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-5195-5p ; hsa-mir-545-5p ; hsa-mir-548t-3p ; hsa-mir-3150a-5p ; hsa-mir-3150b-5p ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-548at-3p ; hsa-mir-548ay-3p ; hsa-mir-582-3p ; hsa-mir-548c-3p ; hsa-mir-4719 ; hsa-mir-218-5p ; hsa-mir-510-3p ; hsa-mir-431-5p ; hsa-mir-4764-5p ; hsa-mir-4738-3p ; hsa-mir-4635 ; hsa-mir-6507-5p ; hsa-mir-6782-5p ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-7109-5p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-513a-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-92a-2-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-608 ; hsa-mir-7110-5p ; hsa-mir-4651 ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-3202 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-27a-3p ; hsa-mir-3681-3p ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-27b-3p ; hsa-mir-548g-3p ; hsa-mir-548av-3p ; hsa-mir-4684-5p ; hsa-mir-942-5p ; hsa-mir-599 ; hsa-mir-3143 ; hsa-mir-5087 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-589-3p ; hsa-mir-410-3p ; hsa-mir-4773 ; hsa-mir-543 ; hsa-mir-101-3p ; hsa-mir-139-5p ; hsa-mir-3675-3p ; hsa-mir-144-3p ; hsa-mir-5692a ; hsa-mir-6801-5p ; hsa-mir-1178-5p ; hsa-mir-3912-3p ; hsa-mir-6873-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6818-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-1304-3p ; hsa-mir-483-3p ; hsa-mir-421 ; hsa-mir-4709-5p ; hsa-mir-1976 ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-450a-1-3p ; hsa-mir-4776-5p ; hsa-mir-6772-3p ; hsa-mir-4303 ; hsa-mir-3619-3p ; hsa-mir-4448 ; hsa-mir-4268 ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-591 ; hsa-mir-6751-3p ; hsa-mir-1199-5p ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6892-3p ; hsa-mir-6865-3p

Nearest miRNA

hsa-mir-3691/Upstream/1033455; hsa-mir-10398/Downstream/3236827;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/61547, chr6-CpG: 91/Downstream/26754

Upstream sequence

ACATGGTCTGACCAACAAAGAAAACTCTATGACTGCTAGATTAACAAATAACTTCAGAGTCTGCTCATTTAAATAAATGTTATTTAAGTAACATTTAAAT

Downstream sequence

AACTTCTGAGGTCTTTTGTTTGTTTTTAAGAATGTCTGACTTTGTATGGACATATTACTATGTATTTTTGTGGATTTTGTAAATAGATATGGGGACCAAA