Basic Information
VIS ID
TVIS10011370
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1934
Orient
+
Integrated sequence
GCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGC| |TACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCT
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
83299180/82589463 (Hg38)
End
83299180/82589463 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/4050154; hsa-mir-1202/Downstream/7723279;
Nearest TSS
ENST00000381078/Upstream/225219; ENST00000451856/Downstream/304570;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/223861, chr6-CpG: 39/Downstream/476192
Nearby gene
TPBG(-222047) ; UBE3D(+303006) ;
Upstream sequence
GGTGTCGGGAGGCTGGCGAAGCCTCCAGGGACGCGGTCAGGGTACCCCTCCCACTCGCGCCGCGGGGACGCATTTCCAGCCTCCCTGAGTTTTTCTGGTC
Downstream sequence
GAGCCATGATTTTGTGGAAGAGAGGGGAGGACCTTTTGGACCAACTGAAGGACTTTCATGatatgctgaccaaatgtatttggtcaataagtggtcctcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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