Basic Information
VIS ID
TVIS10011372
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1965
Orient
+
Integrated sequence
TCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCT| |GACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCAC
Host Sequence
Chromosome
chr7
Cytoband
q36.2
Reference genome
GRCh37/hg19
Start
153356949/153659864 (Hg38)
End
153356949/153659864 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7I
Nearest miRNA
hsa-mir-10399/Upstream/2226225; hsa-mir-153-2/Downstream/3914472;
Nearest TSS
ENST00000635602/Upstream/245901; ENST00000462622/Downstream/227233;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/733644, chr7-CpG: 87/Downstream/88215
Nearby gene
ACTR3B(-804485) ; DPP6(+227470) ;
Upstream sequence
AATGAAACTATCTGTGTGCAGGATAGAATTACTTGTATCAAGTACACCAAGACTTTTAATCCATTTTGTAATCAAACAGGGCATCTCTCTGGGCccctat
Downstream sequence
TTAAATTACTGTGTCCCTTCTAAAGATCTGGAAACAACCTTGATTTTTTTCCCCAGGAAGATACAAAGAGAGAAACAATAATAATCTGATTTACACGTCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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