VISDB Viral Integration Site DataBase

VIS ID

TVIS10011374

Fusion event

HBV-SEMA3E integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2354

Orient

+

Integrated sequence

ATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACG| |ACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAG

Chromosome

chr7

Cytoband

q21.11

Reference genome

Start

End

83001235/83371919 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-615-3p ; hsa-mir-6878-3p ; hsa-mir-6741-3p ; hsa-mir-642a-5p ; hsa-mir-6830-3p ; hsa-mir-3124-3p ; hsa-mir-4778-3p ; hsa-mir-877-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6867-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-4284 ; hsa-mir-2276-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-6890-3p ; hsa-mir-4753-3p ; hsa-mir-222-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-122-3p ; hsa-mir-6722-5p ; hsa-mir-1288-3p ; hsa-mir-6499-3p ; hsa-mir-17-3p ; hsa-mir-5693 ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-1250-3p ; hsa-mir-129-5p ; hsa-mir-153-5p ; hsa-mir-3672 ; hsa-mir-4294 ; hsa-mir-4743-5p ; hsa-mir-4754 ; hsa-mir-4760-3p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-664a-3p ; hsa-mir-664b-3p ; hsa-mir-6812-3p ; hsa-mir-6864-3p ; hsa-mir-8055

Nearest miRNA

hsa-mir-10525/Upstream/7456650; hsa-mir-10399/Downstream/8832096;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/208823, chr7-CpG: 30/Downstream/377650

Upstream sequence

CAGCAGAATTTGCAGCTCCATGTTTCCAAAGCTTCCAGGGCACTTGCATTTAGAGAGAGAGAGCAAGCAAGCTGCCTTTCCTCTTCCTCAGTTCTGCCAG

Downstream sequence

TTTACATTTGTAGCACAAAAGCTGTTATTTATATTTCTTTTCAAATTATTTTTCCACACAAGTTTCATCTCTTCAAACATATAAGTTTTTAAAGGGCAAA