Basic Information
VIS ID
TVIS10011383
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
57181439/56268880 (Hg38)
End
57181439/56268880 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/13372605; hsa-mir-10400/Downstream/5445908;
Nearest TSS
ENST00000518652/Upstream/46192; ENST00000522511/Downstream/51295;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/56442, chr8-CpG: 48/Downstream/50931
Nearby gene
CHCHD7(-50263) ; SDR16C5(+31131) ;
Upstream sequence
atagggtcttgctgtattgcccaggctggagtgtagtggcatgatcatagctcactgcagccttgaccttccaggctcaaatgatcctcccatttcagct
Downstream sequence
AAAGTCTCTCATTTTTAAAAAATTCGCttatattaaaaatattaaataataCAAATGCAGAAAAAGAAAACCTTTTTCTCCAGTCCCCCAAATCCCTCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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