Basic Information
VIS ID
TVIS10011385
Fusion event
HBV-LOC105375897 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1808
Orient
-
Integrated sequence
TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCAC| |CAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGAC
Host Sequence
Chromosome
chr8
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
73430360/72518125 (Hg38)
End
73430360/72518125 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375897
Nearest miRNA
hsa-mir-124-1/Upstream/8138868; hsa-mir-10400/Downstream/2030418;
Nearest TSS
ENST00000518652/Upstream/55814; ENST00000523207/Downstream/19266;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/266169, chr8-CpG: 112/Downstream/18299
Nearby gene
LOC392232(-266491) ; KCNB2(+19266) ;
Upstream sequence
attattattattttttaCAAACCAGGATCCAATAGAAGCTTATGCATTGCTATTTGGGTAATAATCTTTTAATATCTTTTAAAAACACATAACATTTTAA
Downstream sequence
TGATTCAGGTGTGTTTTTCAGGATAGGTTAAGGACTCAGATCCTTGAGTTCTGGATCAATGAATCTGTCTATAGCCTCAGACATAATCTCAGTATTTTAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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