Basic Information
VIS ID
TVIS10011388
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1878
Orient
+
Integrated sequence
GAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAG| |CTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTT
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
8352980/8495470 (Hg38)
End
8352980/8495470 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3674/Upstream/406381; hsa-mir-10400/Downstream/552975;
Nearest TSS
ENST00000518652/Upstream/34133; ENST00000524073/Downstream/64424;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/108701, chr8-CpG: 183/Downstream/206151
Nearby gene
PRAG1(-113723) ; CLDN23(+206686) ;
Nearest cancer related gene
CLDN23(TSG, +206686) ;
Upstream sequence
tgcCTGTACTTATTCTCCACTTGACCCCTTAGCAAGACTCCCTCccccgccagtcattctcccatcttctctggcctgctgtcttcccagaaaataggac
Downstream sequence
gtgaaacctcatctctaccaaaaaatacaaaaaattagccatgcatggtggtgtgtgcctgtagtcccggctacttgggaggctgaagcatgagaatctc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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