Basic Information
VIS ID
TVIS10011392
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1809
Orient
-
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
122313258/119550980 (Hg38)
End
122313258/119550980 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/5341451; hsa-mir-12126/Downstream/693999;
Nearest TSS
ENST00000422679/Upstream/55605; ENST00000561476/Downstream/384073;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/181044, chr9-CpG: 40/Downstream/943779
Nearby gene
BRINP1(-181519) ; MIR147A(+693999) ;
Nearest cancer related gene
BRINP1(TSG, -181519) ; MIR147A(TSG, +693999) ;
Upstream sequence
TCGTGGCCCAGCTGGGAAGCCCCAGCAAGGACACAAGCCTTTATCTCATCTGAACCTGGGGAAAAGCAACCACTGGGAAGGAAGAGCTCAACAGGAGGCT
Downstream sequence
ATACATGTCTTCTGAGACTGAGAAAAACAAAAAAAAAGTGTGAAAATTAAATCAGAAAAGATGAACTTTTAAATTGGAAAAGATCTAATTTCATAGAAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate