Basic Information
VIS ID
TVIS10011396
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2218
Orient
-
Integrated sequence
GGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTT| |CTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTAT
Host Sequence
Chromosome
chr9
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
43380/43380 (Hg38)
End
43380/43380 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1302-9/Upstream/13099; hsa-let-7a-1/Downstream/4806917;
Nearest TSS
ENST00000422679/Upstream/6111; ENST00000620326/Downstream/29294;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/13865, chr9-CpG: 102/Downstream/29580
Nearby gene
FAM138C(-7516) ; FOXD4(+72851) ;
Upstream sequence
tgacaaaggcatagtaacataattgatttccctttgcattctgagtttgagaataattaggtaaatgacatataaatgaacaagaaataattccattgat
Downstream sequence
GGGCCTGGGCTTGGTTGATGGGAGGGAACAAaaagaatatgggccatctgatcacatggctctggttttgagccccagctgtgctacttagtagctgagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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