Basic Information
VIS ID
TVIS10011397
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
-
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
7234182/7234182 (Hg38)
End
7234182/7234182 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/1226278; hsa-let-7a-1/Downstream/11339124;
Nearest TSS
ENST00000422679/Upstream/106275; ENST00000430766/Downstream/552506;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/475310, chr9-CpG: 43/Downstream/565173
Nearby gene
KDM4C(-58534) ; DMAC1(+562309) ;
Nearest cancer related gene
KDM4C(OG, -58534) ;
Upstream sequence
aatcccaacatggcagaaggtgtacagaccccgtgatatagttcctaatgtacagggagaagagaataacattactctcaatatcgcagggagcgtaacc
Downstream sequence
tgtggagcttccatgccccctctgggcaagccaccctcccagcatctctttgtgttcaccaactctctttgttcaagagtttttctagagcttaatttcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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