VISDB Viral Integration Site DataBase

VIS ID

TVIS10011404

Fusion event

HBV-ATRX integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

66

Orient

-

Integrated sequence

AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGT| |GGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACA

Chromosome

chrX

Cytoband

q21.1

Reference genome

Start

End

77006516/77751035 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-mir-21-5p ; hsa-mir-342-5p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-17-5p ; hsa-mir-200c-3p ; hsa-mir-200a-3p ; hsa-mir-129-5p ; hsa-mir-6505-5p ; hsa-mir-7850-5p ; hsa-mir-320e

Nearest miRNA

hsa-let-7f-2/Upstream/745534; hsa-mir-105-1/Downstream/1150159;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/302854, chrX-CpG: 54/Downstream/34482

Upstream sequence

atgtctagtgatttccatatgttgaaccatccttgcatcactgggataaatttcactcgatcatggtgtatcattttttggatgtgctgttgttctgttc

Downstream sequence

tatatacccagtaatgggattgctgggtcaaattgtatttctggtttctagatccttgaggaatagccacactgtcttccacaatggttgaactaattta