Basic Information
VIS ID
TVIS10011405
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1919
Orient
+
Integrated sequence
AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA| |TAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGG
Host Sequence
Chromosome
chrX
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
87598365/88343364 (Hg38)
End
87598365/88343364 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/2439657; hsa-mir-105-1/Downstream/6719777;
Nearest TSS
ENST00000429181/Upstream/592481; ENST00000373111/Downstream/403861;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/2194491, chrX-CpG: 43/Downstream/3091239
Nearby gene
KLHL4(-673315) ; CPXCR1(+403861) ;
Upstream sequence
atatgttgaaccatccttgcatcactgggataaatttcactcgatcatggtgtatcattttttggatgtgctgttgttctgttcaggttttctatttctt
Downstream sequence
catttacttgtaataaaagccttagtcttagtatacttggcctgaGTTtcacttgcgtccatgtgaagagatcaccaaacaggctttgtgtgagcaacaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate