Basic Information
VIS ID
TVIS10011409
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2280
Orient
+
Integrated sequence
GGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATT| |CGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAA
Host Sequence
Chromosome
chrY
Cytoband
q12
Reference genome
GRCh37/hg19
Start
59363416/57217265 (Hg38)
End
59363416/57217265 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12120/Upstream/43737999;
Nearest TSS
ENST00000430575/Upstream/31488775;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/13842, None/Downstream
Nearby gene
IL9R(-19928) ;
Upstream sequence
ccattctattccagtccattagtttcgactccattgcattcgagtgcattccattccgtggctgtccattccattccgtttgatgccattccatacgatt
Downstream sequence
ggttaggggttaggggttaggggttaggggttagggttagggttagggttagggtgtggtgtgtgggtgtgtgtgggtgtggtgtgtgtgggtgtggtgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate