Basic Information
VIS ID
TVIS10011410
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1347
Orient
+
Integrated sequence
TTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTG| |TCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAA
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
163823903/163854666 (Hg38)
End
163823903/163854666 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1512026; hsa-mir-1182/Downstream/2053255;
Nearest TSS
ENST00000473358/Upstream/514411; ENST00000485769/Downstream/700918;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/431356, chr1-CpG: 34/Downstream/466612
Nearby gene
NUF2(-498350) ; PBX1(+704694) ;
Nearest cancer related gene
PBX1(OG, +704694) ;
Upstream sequence
gttggccaggctggtctcgaactcctgacctcaaatgatccgcccgcctcagcctcccaaagtgctgggattacaggcatgagccactgcacctgCCTCC
Downstream sequence
ATTTTTCTACCCTCTTTTCTAGGACGTTTCTGTCAGTTACTATGTGGGAAGCAGTACTTGCTGCTTCTGAGTAGAGAAGATTCTGTGGCAATTCTTGCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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