Basic Information
VIS ID
TVIS10011413
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr11
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
29761177/29739630 (Hg38)
End
29761177/29739630 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/1262082; hsa-let-7a-2/Downstream/5202207;
Nearest TSS
ENST00000527297/Upstream/25721; ENST00000533718/Downstream/242762;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1628956, chr11-CpG: 25/Downstream/276495
Nearby gene
METTL15(-1406123) ; KCNA4(+270111) ;
Upstream sequence
aaagtaaagcatagaaaaggcaacttccccaaggtcataccactaataagtagaagaaagagaattcaacctcaggcttgtctgaacttacagactgcat
Downstream sequence
tcttttttttttttttttttttttttttttttttttttttttttttttttttttgagacagagtctcactctgtcacccaggctggagtgcagtggcgcg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate