Basic Information
VIS ID
TVIS10011420
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3063
Orient
-
Integrated sequence
GACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGG| |GCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCA
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
7604957/7452361 (Hg38)
End
7604957/7452361 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-141/Upstream/488170; hsa-let-7i/Downstream/1787106;
Nearest TSS
ENST00000382841/Upstream/8176; ENST00000345088/Downstream/19575;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/11927, chr12-CpG: 23/Downstream/176046
Nearby gene
CD163L1(-8208) ; CD163(+18455) ;
Upstream sequence
CACATATATATAGTACCTGGCATATGACTGGATGCATAGTGTATGGAATACAATTGGGTATTTAATACataatacctgacaaatagtaggtgctcaaaaa
Downstream sequence
gttttgttgaataaatgaCTAAGTAATTTAGTTAATCTATGTCAAATATATATTTGAAATTGAGAAGAAGTGCAAAAATACAGAAAGTGTGCCAAATGGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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