Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011428
Fusion event
HBV-SBK2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
Start
End
56045075/55533708 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-let-7e/Upstream/145466; hsa-mir-10394/Downstream/2800980;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/2390, chr19-CpG: 20/Downstream/2328
Upstream sequence
cgccactgcagtccacagtccggcctgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaagaaaaaGTTC
Downstream sequence
CTTCCTTATCAAAAACACCAGCCATCCCCGCCCACTCTGCAGCCAGATGCAGTGGGGTCTCTTCTGCGTGTTCACAGCGCTCCTGATCACTGCCGCCACG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.