Basic Information
VIS ID
TVIS10011430
Fusion event
HBV-LINC00158 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
-
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr21
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
26795083/25422771 (Hg38)
End
26795083/25422771 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LINC00158
Nearest miRNA
hsa-let-7c/Upstream/2343379; hsa-mir-155/Downstream/151209;
Nearest TSS
ENST00000624081/Upstream/88946; ENST00000456917/Downstream/1938;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/60600, chr21-CpG: 51/Downstream/139340
Upstream sequence
GGCTTTATTCATCACAAACAATACGGAAATAAGGGGAAATATGAGAGTCCCTTTGCTTCTCTCTAAGTTTTTAGCCTCTTCTTGAATATGTGCCCATGGT
Downstream sequence
GCCTGGTGCCTGCAAGTGTTTTTTGTGAAGGTGGGTGGTTTTGATGCCCTGCTCATGGCATTGGCCGTTAATTGAACCTGACCTTGGCAAGTACTGTCGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate