Basic Information
VIS ID
TVIS10011432
Fusion event
HBV-LINC01847 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2190
Orient
+
Integrated sequence
GGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAG| |TTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTC
Host Sequence
Chromosome
chr5
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
159223206/159796199 (Hg38)
End
159223206/159796199 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01847
Nearest miRNA
hsa-mir-10397/Upstream/4966659; hsa-mir-103a-1/Downstream/678203;
Nearest TSS
ENST00000502646/Upstream/35138; ENST00000641475/Downstream/68881;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/22514, chr5-CpG: 60/Downstream/120130
Nearby gene
LINC01845(-329922) ; ADRA1B(+120534) ;
Upstream sequence
atgtctgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatgtgtAATGGTCTTTGGAGTCTCCATACCATGTAATTAAAGCTATGG
Downstream sequence
ctgctaattttaaggcccttgagtcctctggtgagaactcataataaagggttatgcccttaactggttggatgttgtctctattgattaagtgaacatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate