Basic Information
VIS ID
TVIS10011434
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1713
Orient
-
Integrated sequence
AGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAA| |AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCA
Host Sequence
Chromosome
chr6
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
126943747/126622601 (Hg38)
End
126943747/126622601 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/137888; hsa-mir-1202/Downstream/5169571;
Nearest TSS
ENST00000381078/Upstream/282427; ENST00000485757/Downstream/496003;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/282360, chr6-CpG: 30/Downstream/20902
Nearby gene
CENPW(-273993) ; RSPO3(+496301) ;
Nearest cancer related gene
CENPW(OG, -273993) ;
Upstream sequence
TACCCCTCCCACTCGCGCCGCGGGGACGCATTTCCAGCCTCCCTGAGTTTTTCTGGTCTGAGCCGAGAGTTTGCTCGAGAACTGCCGAGAGTTGCTGGCT
Downstream sequence
ACttttttttttttttttttttttttttttttttttttttttttttttgagacggagtctcgctctgtcgcccaggctggagtgcagtggcgggatctcg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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