Basic Information
VIS ID
TVIS10011439
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr7
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
91360044/91730729 (Hg38)
End
91360044/91730729 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7E
Nearest miRNA
hsa-mir-10525/Upstream/15815460; hsa-mir-10399/Downstream/473286;
Nearest TSS
ENST00000635602/Upstream/87217; ENST00000438114/Downstream/149710;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/463361, chr7-CpG: 35/Downstream/149954
Nearby gene
FZD1(-461912) ; MTERF(+141977) ;
Upstream sequence
CGCTGGTCCCTTGGATCAGAAATTCAGTACCCTTCCCTCCACACCATGCTGTAGACACCTCTTTCCTCTCCTAGACCCGGAACATCCTCTCTTCTTCAGG
Downstream sequence
Ctttttctttttttttttttttttttttttttttttttttttttttttttttttgagacagagtctcactctgtcacccaggctggagtgcagtggcgcg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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