Basic Information
VIS ID
TVIS10011447
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
+
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
104303094/103760472 (Hg38)
End
104303094/103760472 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/3479164; hsa-mir-11399/Downstream/4136751;
Nearest TSS
ENST00000473358/Upstream/10066; ENST00000635102/Downstream/1845531;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/234181, chr1-CpG: 37/Downstream/2320299
Nearby gene
AMY1A(-1783) ; LOC100129138(+312551) ;
Upstream sequence
attgtaaaaaggcaacggctgaaaagtggtactaccacatggttacaggttatgcttaaggacataaaacaagtcggagacatgcagcaaagtttgttac
Downstream sequence
tgaccagtttatgagggtgtcttgaacagtgagctcaaggagtctcaggcctggattccattccaaggtaccctctGtctgactttttcttctattttct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate