Basic Information
VIS ID
TVIS10011450
Fusion event
HBV-WARS2-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr1
Cytoband
p12
Reference genome
GRCh37/hg19
Start
119766549/119223926 (Hg38)
End
119766549/119223926 (Hg38)
Orient
-
Location type
Intronic
Target gene
WARS2-AS1
Nearest miRNA
hsa-mir-101-1/Upstream/2129198; hsa-mir-1182/Downstream/26626661;
Nearest TSS
ENST00000473358/Upstream/77517; ENST00000420059/Downstream/103377;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/83138, chr1-CpG: 25/Downstream/103677
Nearby gene
WARS2(-83254) ; HAO2(+144853) ;
Upstream sequence
TTATCTCATACATTCTAGGAGGCTATCTTATTCCACATGCTAAAATTATTTATGGAGGCAACAAGTAAATTTAATCCATCGTCATCTGCTAGGAGAGTAT
Downstream sequence
AACCATGTTAAATATAATCTTATTATGCTCCCTGCACCTTTTTGATTGCCACTTCCTTTTCTGTCAGTGTCAATTGTTTCTTCACTGCTGGTTTAAGTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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