Basic Information
VIS ID
TVIS10011451
Fusion event
HBV-LOC105371466 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr1
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
160368231/160398441 (Hg38)
End
160368231/160398441 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105371466
Nearest miRNA
hsa-mir-101-1/Upstream/498362; hsa-mir-1182/Downstream/828745;
Nearest TSS
ENST00000473358/Upstream/31374; ENST00000483408/Downstream/2145;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/54893, chr1-CpG: 59/Downstream/1881
Nearby gene
NHLH1(-25593) ; VANGL2(+2133) ;
Upstream sequence
GGTCCCTTAGACCATAGGGCACATGGGCCTTCTAGCTGGGTCTCTGTTTGCTTACTCAGTGACTTGGGGACGTGTGAAATCCAGATGGGATTCTATCCTG
Downstream sequence
AGGTGAAGGTAGAAGGTAATACAGAGAATTGCTGAATGGGACAGACCACACCAATAAAATTTTTTGTTGGACTCTGTAATCCAGTGTTTTCATTGCAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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