VISDB Viral Integration Site DataBase

VIS ID

TVIS10011457

Fusion event

HBV-EPB41 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1941

Orient

+

Integrated sequence

CATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTG| |GAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGC

Chromosome

chr1

Cytoband

p35.3

Reference genome

Start

End

29338785/29012273 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-148b-3p ; hsa-mir-320b ; hsa-mir-877-3p ; hsa-mir-423-5p ; hsa-mir-342-3p ; hsa-mir-320a ; hsa-mir-875-3p ; hsa-mir-7703 ; hsa-mir-196a-3p ; hsa-mir-4252 ; hsa-mir-4537 ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1292-3p ; hsa-mir-4267 ; hsa-mir-1273g-3p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-508-5p ; hsa-mir-6821-5p ; hsa-mir-4665-3p ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-1908-3p ; hsa-mir-1228-3p ; hsa-mir-6720-5p ; hsa-mir-3685 ; hsa-mir-6079 ; hsa-mir-1299 ; hsa-mir-155-3p ; hsa-mir-671-5p ; hsa-mir-6828-5p ; hsa-mir-6128 ; hsa-mir-1236-3p ; hsa-mir-140-3p ; hsa-mir-6779-3p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p

Nearest miRNA

hsa-mir-12136/Upstream/2457680; hsa-mir-101-1/Downstream/1726883;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/96816, chr1-CpG: 384/Downstream/108914

Nearest cancer related gene

EPB41(TSG, No orient, 0)

Upstream sequence

AGTAACAGAAGGTGGAAAAGAACAAAGATGAGAAAAGAAAAAGGATATGGGAGTCAGTTCTCAAAATGGTAGTGACTTGAAACCGCAGTTGCCTACTAGG

Downstream sequence

AGTTTGCTGCCGTATCCTATTCCTTTGAAATTGTTCTGAACTATTGCATTATAAATTTTATGTTTTCCTCTTTATGGTTGTTTTCATCCCTTTTAACAGT