VISDB Viral Integration Site DataBase

VIS ID

TVIS10011458

Fusion event

HBV-EPB41 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1791

Orient

-

Integrated sequence

CCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA| |TAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT

Chromosome

chr1

Cytoband

p35.3

Reference genome

Start

End

29338788/29012276 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-148b-3p ; hsa-mir-320b ; hsa-mir-877-3p ; hsa-mir-423-5p ; hsa-mir-342-3p ; hsa-mir-320a ; hsa-mir-875-3p ; hsa-mir-7703 ; hsa-mir-196a-3p ; hsa-mir-4252 ; hsa-mir-4537 ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1292-3p ; hsa-mir-4267 ; hsa-mir-1273g-3p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-508-5p ; hsa-mir-6821-5p ; hsa-mir-4665-3p ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-1908-3p ; hsa-mir-1228-3p ; hsa-mir-6720-5p ; hsa-mir-3685 ; hsa-mir-6079 ; hsa-mir-1299 ; hsa-mir-155-3p ; hsa-mir-671-5p ; hsa-mir-6828-5p ; hsa-mir-6128 ; hsa-mir-1236-3p ; hsa-mir-140-3p ; hsa-mir-6779-3p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p

Nearest miRNA

hsa-mir-12136/Upstream/2457683; hsa-mir-101-1/Downstream/1726880;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/96819, chr1-CpG: 384/Downstream/108911

Nearest cancer related gene

EPB41(TSG, No orient, 0)

Upstream sequence

AACAGAAGGTGGAAAAGAACAAAGATGAGAAAAGAAAAAGGATATGGGAGTCAGTTCTCAAAATGGTAGTGACTTGAAACCGCAGTTGCCTACTAGGAGT

Downstream sequence

TTGCTGCCGTATCCTATTCCTTTGAAATTGTTCTGAACTATTGCATTATAAATTTTATGTTTTCCTCTTTATGGTTGTTTTCATCCCTTTTAACAGTCCT