Basic Information
VIS ID
TVIS10011465
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
-
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
88277343/87811660 (Hg38)
End
88277343/87811660 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1D
Nearest miRNA
hsa-mir-101-1/Upstream/1453973; hsa-mir-11399/Downstream/6035172;
Nearest TSS
ENST00000473358/Upstream/440005; ENST00000436111/Downstream/94054;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/476111, chr1-CpG: 63/Downstream/650940
Nearby gene
LINC01364(-440005) ; PKN2(+872579) ;
Upstream sequence
GCTTGGATTCTGCATGCACATGTGTTGCCCATTGACCTGGGGCCCTGAGACTTCCTCTTGGAAAACCTGGTACATAATATTTTCTAATTTGTACTAGTCA
Downstream sequence
AGTTCTTTGGACACCATGCCTTGCATAGCTTTTCTGTGTTTATGAGAGTTACCATTAATGATTACAACCAAGTTCCCAGGTAAGTAATTATCAACTATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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