Basic Information
VIS ID
TVIS10011467
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
46722199/46827389 (Hg38)
End
46722199/46827389 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
AGAP13P ; LOC107984026
Nearest miRNA
hsa-mir-1265/Upstream/1663301; hsa-mir-107/Downstream/2158123;
Nearest TSS
ENST00000439456/Upstream/195002; ENST00000506881/Downstream/84007;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/40243, chr10-CpG: 19/Downstream/10330
Nearby gene
BMS1P1(+15414) ;
Upstream sequence
agttctaggagctttttggaggagtctttagggtttcctaggtatatgatcatatcatcatcaaacagcaacagtttgacttcctctttactgatctgca
Downstream sequence
tgccttttattgttttctcttgtgtgattgctctggctaggccttccagtagtatgttgaatacaagtggtgagagtgggcatccttgtcttgttccagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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