Basic Information
VIS ID
TVIS10011472
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr11
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
102812014/102941285 (Hg38)
End
102812014/102941285 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10392/Upstream/1421380; hsa-let-7a-2/Downstream/908621;
Nearest TSS
ENST00000527297/Upstream/66251; ENST00000533027/Downstream/14420;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/488254, chr11-CpG: 66/Downstream/150260
Nearby gene
MMP12(-66250) ; MMP13(+1707) ;
Nearest cancer related gene
MMP12(OG, -66250) ;
Upstream sequence
TCTCACAGCGTCGTGATGAATCCGTAAATCAAGGTATTTTCTGTGACCAGGGCTTaatccactcctgttggctccgagaaaactgtgcgtgcagagagct
Downstream sequence
gcacttttttttctaaacgggaagtgagttAAACTTGGTAGCTTTTATGGTGGCTATCTTTCTGTTATATATGTTTTCGTGTTTTTATTCTGACATGAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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