Basic Information
VIS ID
TVIS10011476
Fusion event
HBV-JAML integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2150
Orient
-
Integrated sequence
CTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGA| |CCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATA
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
End
118073330/118202615 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10392/Upstream/4752527; hsa-let-7a-2/Downstream/441385;
Upstream sequence
CTCTGCCTCAGGATGGCAGGGCAGAGATAAGAATGGGGGAGACATAGATATGTTTGTGGGTGGAGAAGCTGCATGAGCCCCCATAATGGCTCGATTTTCT
Downstream sequence
CTGTGAATTGGACTTCTGAGAAGGAAGCACACAGACCTGCCGTGCTCCCCTCTCCAGCTGGAGACAAGGTGCCTCCACAGACTTAGGTCTCTGGCCTGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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