Basic Information
VIS ID
TVIS10011483
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
11757913/11604979 (Hg38)
End
11757913/11604979 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/2365428; hsa-let-7i/Downstream/506973;
Nearest TSS
ENST00000382841/Upstream/48013; ENST00000544715/Downstream/44875;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/104138, chr12-CpG: 81/Downstream/43940
Nearby gene
LINC01252(-40578) ; ETV6(+44875) ;
Nearest cancer related gene
ETV6(OG, +44875) ;
Upstream sequence
tacaaaaggggaaatgtatactctactttcaggcagtcacagggagacaggagcttttcctgcatcggatagttttcaattggctttaactcaaaataat
Downstream sequence
ctatatgacaaagaggcatattttgaggtggcatattcatataccctgcatcataCCCCAATCATTTCTTCAACTTAATATTCAGCAATCCCTGGGATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate