Basic Information
VIS ID
TVIS10011490
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1703
Orient
-
Integrated sequence
CGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGG| |CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG
Host Sequence
Chromosome
chr12
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
63552086/63158306 (Hg38)
End
63552086/63158306 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/554537; hsa-mir-10527/Downstream/665357;
Nearest TSS
ENST00000382841/Upstream/7364; ENST00000536219/Downstream/201731;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/7119, chr12-CpG: 97/Downstream/509750
Nearby gene
AVPR1A(-5496) ; DPY19L2(+400607) ;
Upstream sequence
AAGAGGTTTGATCCATTGGATTGCAACCTCAATGTACATGAGAAAGTTTCTAAGATTAAATTTCTCTGAATATATTTAAAGTATGGACACGAAATGGAAT
Downstream sequence
AGGCTTGAAATATTTAGGGCTTTACCTCAGTGTTCCTGAACAGACTTTTACGTGGAAATGTTCTTTGATTACCTGGTAAGTCAACAGGAAGAAATAACAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate