Basic Information
VIS ID
TVIS10011494
Fusion event
HBV-LOC107984561 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2388
Orient
+
Integrated sequence
TCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCG| |CCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACT
Host Sequence
Chromosome
chr13
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
52380008/51805872 (Hg38)
End
52380008/51805872 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107984561
Nearest miRNA
hsa-mir-15a/Upstream/253205; hsa-mir-1267/Downstream/1004178;
Nearest TSS
ENST00000623511/Upstream/1575; ENST00000242819/Downstream/39278;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1435, chr13-CpG: 118/Downstream/205306
Nearby gene
DHRS12(-1710) ; TMEM272(+7475) ;
Upstream sequence
AAATCAAGCATCCACGAGGTAGTTAGTGTATACATTATATACATTTAAAGAGGAGGTCTTAGGAAAAGCCAAACCCTGTCTCAAAATGAGCTTCCACTCT
Downstream sequence
CACCTGGATGCCAAGTAACACACACACACAAACAaagggcagtatggagttcacaagggaatgttcccgtttaactggagtcagctgagctggattctag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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