Basic Information
VIS ID
TVIS10011495
Fusion event
HBV-LOC107984561 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1821
Orient
-
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr13
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
52380032/51805896 (Hg38)
End
52380032/51805896 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107984561
Nearest miRNA
hsa-mir-15a/Upstream/253229; hsa-mir-1267/Downstream/1004154;
Nearest TSS
ENST00000623511/Upstream/1599; ENST00000242819/Downstream/39254;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1459, chr13-CpG: 118/Downstream/205282
Nearby gene
DHRS12(-1734) ; TMEM272(+7451) ;
Upstream sequence
AGTGTATACATTATATACATTTAAAGAGGAGGTCTTAGGAAAAGCCAAACCCTGTCTCAAAATGAGCTTCCACTCTCACCTGGATGCCAAGTAACACACA
Downstream sequence
CACACAAACAaagggcagtatggagttcacaagggaatgttcccgtttaactggagtcagctgagctggattctagtccaatttctgccagttattccct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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