Basic Information
VIS ID
TVIS10011496
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1844
Orient
+
Integrated sequence
GGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCAT| |CTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAG
Host Sequence
Chromosome
chr13
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
64508108/63933975 (Hg38)
End
64508108/63933975 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/2734095; hsa-mir-1267/Downstream/2032355;
Nearest TSS
ENST00000623511/Upstream/185976; ENST00000437777/Downstream/142036;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/89429, chr13-CpG: 92/Downstream/3296401
Nearby gene
OR7E156P(-191407) ;
Upstream sequence
TGGAGTTAATAAAGGTGTTTACCACCTTTAAGCttttaaatatactcaaatattcatcatttttgctctcttgattctgacttgtggatccagttttcta
Downstream sequence
tgtggtaccatcttccttttgtctgaagatgttacatttttatatttattgtggtgaagttctgctaaccatgttttctgaaagtctttatttaccttta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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