Basic Information
VIS ID
TVIS10011497
Fusion event
HBV-LOC112268121 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2065
Orient
+
Integrated sequence
GACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCAC| |TCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTA
Host Sequence
Chromosome
chr13
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
78372303/77798168 (Hg38)
End
78372303/77798168 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
LOC112268121
Nearest miRNA
hsa-mir-1297/Upstream/100052; hsa-mir-1267/Downstream/9820497;
Nearest TSS
ENST00000623511/Upstream/55063; ENST00000422405/Downstream/30054;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/99397, chr13-CpG: 70/Downstream/120122
Nearby gene
SLAIN1(-33926) ; EDNRB(+97313) ;
Upstream sequence
taattttattagaaactactggacagttttacacagcagttgttccatcagcaatgaacttcattcagttcacatctttaccaatatttagAGgggacat
Downstream sequence
tcatgtttgtagcccagagagaccatagaaaagtttatctaccttgaagcctctatactgtgagaaatctctggctacacggagaagccatgtagcttct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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