Basic Information
VIS ID
TVIS10011498
Fusion event
HBV-LOC112268121 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr13
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
78373066/77798931 (Hg38)
End
78373066/77798931 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
LOC112268121
Nearest miRNA
hsa-mir-1297/Upstream/100815; hsa-mir-1267/Downstream/9819734;
Nearest TSS
ENST00000623511/Upstream/55826; ENST00000422405/Downstream/29291;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/100160, chr13-CpG: 70/Downstream/119359
Nearby gene
SLAIN1(-34689) ; EDNRB(+96550) ;
Upstream sequence
ggaatttccatcttccaaaatgctactgacatatactgtttcctttagtctcatctacaattctttttgttcttattaatttgtatcatttttatccttc
Downstream sequence
attctaaattttagagcttgaggagtgctagagataaatgcatttgtttaatccagcccctttagcttgaaatcCCTGCTTGAGTGTGTCAAACCAGTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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