Basic Information
VIS ID
TVIS10011499
Fusion event
HBV-LINC00331 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2262
Orient
+
Integrated sequence
TTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTG| |TCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCA
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
79406828/78832693 (Hg38)
End
79406828/78832693 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA13E
Target gene
LINC00331
Nearest miRNA
hsa-mir-1297/Upstream/1134577; hsa-mir-1267/Downstream/8785972;
Nearest TSS
ENST00000623511/Upstream/40386; ENST00000607864/Downstream/508519;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/173411, chr13-CpG: 65/Downstream/573176
Upstream sequence
AAAATCCTGGCGCAGCATCTCCCCTCTTAAGTTTCTGGCAGGTGTGTGCTAGATCCAGCCTACTAAATACTGCGTAATTAGAACGCCTTGGGCAATCACT
Downstream sequence
GTCATCCTACATCTGTAAGGCAGTGAGGGCAGTGTTAGCATGACTGTGCTCATTTCTTTAACATCCCATGCTTATAGACCCAAACACAGCTGCCTGAAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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