VISDB Viral Integration Site DataBase

VIS ID

TVIS10011503

Fusion event

HBV-MDGA2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2030

Orient

+

Integrated sequence

GAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGA| |GTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTG

Chromosome

chr14

Cytoband

q21.3

Reference genome

Start

End

47933376/47464173 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-153-5p ; hsa-mir-1250-3p

Nearest miRNA

hsa-mir-208a/Upstream/10511782; hsa-mir-1185-1/Downstream/296822;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/812217, chr14-CpG: 186/Downstream/210057

Upstream sequence

TTAAAATTCATTTCTCACTTACTATGTacacacacacacacacacacacacacacacacacacacacacacaGAGCCTCTGTTGCTTTGTTGGTATCAGC

Downstream sequence

AGACATAAATCAGAGCTGACTGGACCTGAGATGGACCAAAGGTGGATGTGAGATCCAGGATAAAATAACACAAGGGATAGGAAAAATTAATCAAATTCTC