VISDB Viral Integration Site DataBase

VIS ID

TVIS10011504

Fusion event

HBV-GPHN integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1765

Orient

-

Integrated sequence

TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT

Chromosome

chr14

Cytoband

q24.1

Reference genome

Start

End

67899094/67432377 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-375

Nearest miRNA

hsa-mir-208a/Upstream/1961191; hsa-mir-1185-1/Downstream/9478;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/19927, chr14-CpG: 40/Downstream/41080

Nearby gene

PLEK2(-20266) ; TMEM229B(+37889) ;

Upstream sequence

aatggcaggaccaagatttagaccctggtggtcagagcccaacttctgaagcctttgaattacaccacactgcctTCCTTGGCGAACGAGCCCTGGTTCT

Downstream sequence

TAGAACCTGGAATGTGCCATAAATAGTTCGCCTTCTGCAAAGAGAGACTTGCAGTTGGTCAGGAAACAGAAAAATATCTCCTGTCTTGAGTATTTACCTT