Basic Information
VIS ID
TVIS10011508
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
36678424/36386223 (Hg38)
End
36678424/36386223 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1233-1/Upstream/459300; hsa-mir-10393/Downstream/586598;
Nearest TSS
ENST00000557528/Upstream/44484; ENST00000567573/Downstream/58289;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/839909, chr15-CpG: 35/Downstream/193035
Nearby gene
MIR4510(-459300) ; C15orf41(+193388) ;
Upstream sequence
TTCCTTAAAAGAGTTAAATTTCCCAAAGTTTTTTAAAAGTGGCTCATTGAAAAAATAATTAAGTAGATAAAAGTATCACATTCTGAGCCCTCATACAGAT
Downstream sequence
GTTCAGAGTATGAAAGCATTGGGCTACATAACTGCAACTTACCATGCATTACCATGTACTATACTGCATACGTTCCCAAGTTACTTCAGGGAAGACAAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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