Basic Information
VIS ID
TVIS10011510
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1890
Orient
+
Integrated sequence
ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG| |TGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATC
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
46707455/46415257 (Hg38)
End
46707455/46415257 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/982128; hsa-mir-11181/Downstream/2753813;
Nearest TSS
ENST00000557528/Upstream/710062; ENST00000559148/Downstream/278031;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/710051, chr15-CpG: 96/Downstream/768915
Nearby gene
SQOR(-723976) ; SEMA6D(+768948) ;
Upstream sequence
ttatccagattgtatactgcacaagggtacccaactgaaggagcaagtgggagctgcaaGCAGGGTGCCTTGGGTAGATGCATCCACCTGAAGGCAGGCA
Downstream sequence
TGCTATTGCTAATCCCACTCTAGGGTATTGGCTTAGGGTATTCTGAAAAGTGAGATTCACCCATTTGTTCTATGATCTGAAAAGGTCTGAAATATACCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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