Basic Information
VIS ID
TVIS10011512
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
-
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
49395138/49102941 (Hg38)
End
49395138/49102941 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/3669812; hsa-mir-11181/Downstream/66129;
Nearest TSS
ENST00000557528/Upstream/1150; ENST00000559095/Downstream/27832;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/56367, chr15-CpG: 51/Downstream/52201
Nearby gene
SECISBP2L(-56378) ; COPS2(+22333) ;
Nearest cancer related gene
COPS2(TSG, +22333) ;
Upstream sequence
gtaatcccagctactcgggaggctgaggaaggagaatcgcttgaacccgggaaacggaggttgcggtgagccaaaatcgtgctattgcactccagcctag
Downstream sequence
gcaacaagagtgaaactctgtctcaaaaacaaaaaaacaaaaaacaaaacaaaaAAAACCACATTATGACACCTACAGGCTAATTCATGTAGAGAACCAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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