Basic Information
VIS ID
TVIS10011514
Fusion event
HBV-UBE2Q2P2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1887
Orient
+
Integrated sequence
GGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTT| |GGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAG
Host Sequence
Chromosome
chr15
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
82698571/82406365 (Hg38)
End
82698571/82406365 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
UBE2Q2P2
Nearest miRNA
hsa-mir-10393/Upstream/1408892; hsa-mir-11181/Downstream/660970;
Nearest TSS
ENST00000557528/Upstream/56890; ENST00000558668/Downstream/23653;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/50406, chr15-CpG: 81/Downstream/38775
Upstream sequence
TCTGTTTAGTCTTAGGATAAGATATGGATGTGTTTTCATCTTTAGAGAAGTCCCTGCACTGAAAAACTGAAACCAGTTGCATGTAGGCACACGTGGTTCT
Downstream sequence
CAGTGTCTTAATGTGTGAACTAGACCATCTGTGTAATATTCTTGCTTGTAGTCTTATGAATGGAAGCCTATTTTACTTAATATTGTGTCACCTTGAGTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate